m6A Demethylase FTO Regulates Dopaminergic Neurotransmission Deficits Caused by Arsenite
نویسندگان
چکیده
منابع مشابه
Ipsilateral deficits of dopaminergic neurotransmission in Parkinson's disease
OBJECTIVE The nigral lesion and the resulting contralateral motor signs of Parkinson's disease (PD) are remarkably asymmetric. This study investigated the prevalence of patients with "wrong-sided" lesions, that is, patients with symptoms on the side ipsilateral to the predominant dopaminergic nigrostriatal deficit. METHODS The analyzed sample included 434 early unmedicated PD patients from th...
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Two human demethylases, the fat mass and obesity-associated (FTO) enzyme and ALKBH5, oxidatively demethylate abundant N(6)-methyladenosine (m(6)A) residues in mRNA. Achieving a method for selective inhibition of FTO over ALKBH5 remains a challenge, however. Here, we have identified meclofenamic acid (MA) as a highly selective inhibitor of FTO. MA is a non-steroidal, anti-inflammatory drug that ...
متن کاملN6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing
N6-methyladenosine (m6A) is the most abundant base modification found in messenger RNAs (mRNAs). The discovery of FTO as the first m6A mRNA demethylase established the concept of reversible RNA modification. Here, we present a comprehensive transcriptome-wide analysis of RNA demethylation and uncover FTO as a potent regulator of nuclear mRNA processing events such as alternative splicing and 3΄...
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The aim of this research was to investigate the Cyclooxygenase-2 (COX-2) selective inhibition effect on haloperidol-induced catatonia. In this study, the effect of orally, acutely and Sub-chronically administrations of compound 11b [1-(phenyl)-5-(4-methylsulfonylphenyl)-2-ethylthioimidazole] (2, 4 and 8 mg/kg), a newly selective COX-2 inhibitor, was investigated against the haloperidol-induced ...
متن کاملSelective Cyclooxygenase-2 Inhibitor Compound 11b Improves Haloperidol-Induced Catatonia by Enhancing the Striatum Dopaminergic Neurotransmission
The aim of this research was to investigate the Cyclooxygenase-2 (COX-2) selective inhibition effect on haloperidol-induced catatonia. In this study, the effect of orally, acutely and Sub-chronically administrations of compound 11b [1-(phenyl)-5-(4-methylsulfonylphenyl)-2-ethylthioimidazole] (2, 4 and 8 mg/kg), a newly selective COX-2 inhibitor, was investigated against the haloperidol-induced ...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2018
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfy172